坊間常見標榜「無雙酚A」（BPA-free）的水瓶、奶瓶和保鮮盒。雖然雙酚A使用仍然合法，但隨著近年來食安意識的提升，消費者仍青睞標榜不含雙酚A的商品，塑膠業者因此必須尋找替代品，像是「雙酚笏」（fluorene-9-bisphenol，或縮寫BHFP）。
不過，《自然通訊》期刊上月底一項新研究顯示，雙酚笏會使大鼠發生子宮病變和流產。這類化學物質雖然對動物有影響，但對人體的效果仍很難評估。
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連結：Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice
Bisphenol A (BPA) is used in the production of plastic but has oestrogenic activity. Therefore, BPA substitutes, such as fluorene-9-bisphenol (BHPF), have been introduced for the production of so-called ‘BPA-free’ plastics. Here we show that BHPF is released from commercial ‘BPA-free’ plastic bottles into drinking water and has anti-oestrogenic effects in mice. We demonstrate that BHPF has anti-oestrogenic activity in vitro and, in an uterotrophic assay in mice, induces low uterine weight, atrophic endometria and causes adverse pregnancy outcomes, even at doses lower than those of BPA for which no observed adverse effect have been reported. Female mice given water containing BHPF released from plastic bottles, have detectable levels of BHPF in serum, low uterine weights and show decreased expressions of oestrogen-responsive genes. We also detect BHPF in the plasma of 7/100 individuals, who regularly drink water from plastic bottles. Our data suggest that BPA substitutes should be tested for anti-oestrogenic activity and call for further study of the toxicological effects of BHPF on human health.
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