法國尼斯大學團隊於「歐洲心臟病學會」年會上發表研究指出，法國自2009至2012年，用來提神的機能飲料總消耗量增加3成，高達5000萬公升。而在4年內通報200多例因飲用機能飲料而引發不適症狀個案中，有近半數是因出現心律不整、心絞痛及高血壓等心血管疾病症狀就醫，其中更有9人死於心肌梗塞。
尼斯大學臨床藥理學教授米羅丹尼爾德雷希分析，市售逾96%的機能飲料都含有高濃度咖啡因。以250毫升的機能飲料為例，咖啡因含量幾乎等於2份義式濃縮咖啡；若在短時間內大量飲用，雖能促進心臟氧氣運用效率，但也會造成心肌細胞過度釋放鈣離子，因而引發心律不整。
德雷希表示，法國民眾最常豪飲機能飲料的場所，是健身俱樂部及夜店，而「夜店咖」飲用機能飲料的方式，類似我國的維士比及保力達B等提神藥酒，也就是將酒類與機能飲料「混搭」後飲用，常導致咖啡因攝取過量，而出現包括心跳過快、肢體顫抖、焦慮及頭痛等「咖啡因症狀」。
連結：Energy drinks cause heart problems（「歐洲心臟病學會」報告）
The current study analysed adverse events reported to the agency between 1 January 2009 and 30 November 2012. Some 15 specialists including cardiologists, psychiatrists, neurologists and physiologists contributed to the investigation. The findings were compared to published data in the scientific literature.
The researchers found that consumption of the 103 energy drinks in France increased by 30% between 2009 and 2011 up to over 30 million litres. The leading brand made up 40% of energy drinks consumed. Two-thirds of drinks were consumed away from home.
During the two year period 257 cases were reported to the agency, of which 212 provided sufficient information for food and drug safety evaluation. The experts found that 95 of the reported adverse events had cardiovascular symptoms, 74 psychiatric, and 57 neurological, sometimes overlapping. Cardiac arrests and sudden or unexplained deaths occurred at least in 8 cases, while 46 people had heart rhythm disorders, 13 had angina and 3 had hypertension.
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